In seguito alla morte della moglie Martha, per mano di una folla inferocita, il Conte Dracula decide di erigere l'Hotel Transylvania, un albergo a cinque stelle destinato al soggiorno di tutti i mostri del mondo, lontano dagli umani, come nuova dimora sicura per crescere la sua figlia adolescente Mavis.
2 Houses and rooms are full of perfumes, the shelves are crowded with perfumes, I breathe the fragrance myself and know it and like it, The distillation would intoxicate me also, but I shall not let it. Have you felt so proud to get at the meaning of poems?
The atmosphere is not a perfume, it has no taste of the distillation, it is odorless, It is for my mouth forever, I am in love with it, I will go to the bank by the wood and become undisguised and naked, I am mad for it to be in contact with me. Stop this day and night with me and you shall possess the origin of all poems, You shall possess the good of the earth and sun, (there are millions of suns left,) You shall no longer take things at second or third hand, nor look through the eyes of the dead, nor feed on the spectres in books, You shall not look through my eyes either, nor take things from me, You shall listen to all sides and filter them from your self.
Tra i mostri ospitati nell'albergo ci sono il mostro di Frankenstein, detto Frank, e sua moglie Eunice, la famiglia di lupi mannari composta da Wayne e Wanda con la loro nutrita cucciolata, Murray la mummia e Griffin, l'uomo invisibile.
Al centodiciottesimo compleanno della figlia, Dracula le permette di uscire dall'albergo per visitare il mondo degli umani.